Knowledge is power, or so they say – but in A Wrinkle in Time, not knowing, or at least being aware that you don't know, is even more powerful. The real danger is thinking that you know more than you do. In the many worlds of this novel, there's much more out there in the universe than the average human brain is even able to comprehend – so recognizing one's limitations is the first step to being able to be at least indirectly aware of all the splendors out there beyond one's grasp. And what would the universe be without some mystery in it?
By focusing as much on the unknown as the known, the novel portrays the search for knowledge less as active conquest and more as a passive act of wonder, suggesting that knowledge is produced by being receptive to one's surroundings rather than by seeking to dominate them.
By having Meg be brilliant and yet be a failure as a student, the novel suggests that knowledge comes from within rather than from education.