Tony Kushner really busts the seams with his epic Angels in America. It just doesn't fit at all into the classic plot analysis. Part of the issue is that it's hard to analyze Millennium Approaches separately from Perestroika. Another issue is that Millennium Approaches seems to have a few mini climaxes, instead of building to one large climax, and then petering off into a denouement and conclusion. Still, we'll try to fill in some details where they're relevant.
The initial situation for our two sets of couples – Prior and Louis, Joe and Harper – doesn't last long. If we were to describe an initial situation for each pair, though, we'd say that Prior and Louis seem to be in a happy, committed relationship, while Joe and Harper are in an unhappy, but relatively stable relationship.
Quickly, a conflict arises in each couple's relationship. Prior tells Louis that he has AIDS, which really terrifies Louis. Joe tells Harper about his new job offer, but she has no interest in moving to Washington, DC, with him.
Both of the relationships in the play become more strained as the play goes on. Louis just can't seem to cope with Prior's increasingly serious illness and the deterioration of his heath. When Prior winds up in the hospital, Louis is clearly contemplating leaving his lover but feels horribly guilty about it. Meanwhile, Harper becomes increasingly suspicious that Joe is gay, though Joe refuses to admit it.
This play seems to have a few mini climaxes:
The play ends on a note of suspense. Really, we have a lot of questions: What's the deal with the angel? What's all this talk of Prior being a prophet? What the heck is the "Great Work" that's about to begin? (3.7.47). What will happen between Louis and Joe? I guess we'll just have to read Part Two: Perestroika to find out.