In Millennium Approaches, the first part of Angels in America, we see each character slowly become more and more isolated over the course of the play. There's still plenty of isolation in Perestroika, but by the end of the play the characters have come together again in new and unexpected ways. Most have grown stronger as a result of their isolation. For example, Harper and Prior, who were each abandoned, find the strength to reject the lovers who deserted them. Both characters have grown from the pain that their isolation has caused.
Over the course of Perestroika, the conservative characters become increasingly isolated, while the liberal ones form new communities.
The shared dreams that exist in the play present the hopeful idea that perhaps ultimately we are not alone.