The play is set up as an interaction between Rome and Alexandria, Egypt. That the settings mirror each other is a convenient device to interpret the meaning of the characters’ actions. Values, morals and meanings are changed with each setting in the play, and the interaction of these places is a way to understand the struggles that Antony has to go through, while also informing how Cleopatra acts and makes judgments. Contrasting regions provide a lens of interpretation that is neither good nor bad, but depends on regional values and differences.
Antony’s downfall at the end of the play is a direct result of his loss of place. He doesn’t stand for the regimented reality of Rome anymore, but he can’t totally give himself up to the "life is good" mentality of Egypt. In Antony and Cleopatra, a man without a place has no place in the world.
Shakespeare presents Roman ideals as superior to Egyptian ideals in Antony and Cleopatra. Unlike most pastorals, Egypt isn’t just presented as a convenient place to take a holiday from Rome, but it stands as the evil contrast to the good of Rome. This is proven by the fact that Antony and Cleopatra, both inextricably tied to Egypt, fall at the end of the play, whereas Rome and Roman characters triumph.