"The Birthmark" is interested in Nature as the personified creator of all things. It tells the story of a man who challenges Nature in trying to become a creator of sorts himself, in trying to "repair" a "flaw" that Nature has left on another human being. One of the many morals of the story is that Nature, like a "jealous patentee," carefully guards her secrets and can't be beaten or even matched by man. Part of the problem with the unbounded scientific urge, Hawthorne argues, is that it ignores the natural boundaries Nature sets for man's accomplishments.
Aylmer only wants to remove the birthmark from Georgiana's cheek for the scientific thrill. It's about his own ego, not about her.
Through his physical descriptions of setting, Hawthorne suggests that much of science is deceptive to its spectators.