Certainly all of Cannery Row and probably all of Monterey felt that a change had come. It's all right not to believe in luck and omens. Nobody believes in them. But it doesn't do to take chances with them and no one takes chances (25.1)
It's not that Mack and the boys' time in the doghouse somehow gave the whole town bad luck ... but it did. Yeah, it sounds crazy. But we think Steinbeck's point is that everything—and we mean everything—is connected.