If you are working for an employer, your freedom with regard to your research may be limited, but you will have slightly more job security and will not need to worry about fulfilling the terms of a grant, so the level of stress may be less. It can also be quite frustrating to work toward a goal for years without your research bearing much fruit. Unless you enjoy the journey more than reaching the destination. However, any time you’re feeling overwhelmed, you can simply kick back and relax with the latest issue of Antimicrobial Agents and Chemotherapy. That should take your mind off things.