The qualifications are technically none. If you can convince some actor you’re going to make his life better, and he agrees to pay you in return, boom - you’re a talent manager. But if you want to reel in the really big fish, you should have a good reputation in the industry, a slew of favorable connections, and a keen business sense. In fact, a business degree may not be a bad idea. Although you’ll probably instead want to spend those four years of your life starving on the streets of Culver City.