In The Curious Incident of the Dog in the Night-Time, Christopher is isolated, and so totally psyched about it. He doesn't like being around people, really doesn't enjoy talking, and absolutely hates being touched. When he wants to relax, he just crams himself into the smallest space he can fit into, and hangs out there for a few hours. But at the same time, he's deeply connected to the world around him. He understands things that few of us could dream of grasping (for example, astrophysics), and notices his surroundings in more detail than we could ever imagine. In fact, one reason he likes being shut into dark spaces is because he experiences the world around him so intensely that it's simply overwhelming; only with distance can he really relax and process all that information. So in a way, the more isolated he is, the more connected he becomes.