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After having made a few preparatory experiments, he concluded with a panegyric upon modern chemistry, the terms of which I shall never forget: "The ancient teachers of this science," said he, "promised impossibilities and performed nothing. The modern masters promise very little; they know that metals cannot be transmuted and that the elixir of life is a chimera but these philosophers, whose hands seem only made to dabble in dirt, and their eyes to pore over the microscope or crucible, have indeed performed miracles. They penetrate into the recesses of nature and show how she works in her hiding-places. They ascend into the heavens; they have discovered how the blood circulates, and the nature of the air we breathe. They have acquired new and almost unlimited powers; they can command the thunders of heaven, mimic the earthquake, and even mock the invisible world with its own shadows. (3.14)
This professor of Victor’s gives him a way to see scientific inquiry as stemming from older traditions. This respect for the old combined with an interest in the new is what allows Victor to go forward in his scientific explorations.
My departure was therefore fixed at an early date, but before the day resolved upon could arrive, the first misfortune of my life occurred—an omen, as it were, of my future misery. Elizabeth had caught the scarlet fever; her illness was severe, and she was in the greatest danger. During her illness many arguments had been urged to persuade my mother to refrain from attending upon her. She had at first yielded to our entreaties, but when she heard that the life of her favourite was menaced, she could no longer control her anxiety. She attended her sickbed; her watchful attentions triumphed over the malignity of the distemper—Elizabeth was saved, but the consequences of this imprudence were fatal to her preserver. (3.1)
Caroline Frankenstein dies because she loves Elizabeth so much that she insists on taking care of her when she's sick with scarlet fever. So, her death really is an omen—it's a warning that family can be fatal. Think about that the next time your parents tell you to call more often.
She died calmly, and her countenance expressed affection even in death. I need not describe the feelings of those whose dearest ties are rent by that most irreparable evil, the void that presents itself to the soul, and the despair that is exhibited on the countenance. It is so long before the mind can persuade itself that she whom we saw every day and whose very existence appeared a part of our own can have departed forever--that the brightness of a beloved eye can have been extinguished and the sound of a voice so familiar and dear to the ear can be hushed, never more to be heard. These are the reflections of the first days; but when the lapse of time proves the reality of the evil, then the actual bitterness of grief commences. Yet from whom has not that rude hand rent away some dear connection? And why should I describe a sorrow which all have felt, and must feel? The time at length arrives when grief is rather an indulgence than a necessity; and the smile that plays upon the lips, although it may be deemed a sacrilege, is not banished. My mother was dead, but we had still duties which we ought to perform; we must continue our course with the rest and learn to think ourselves fortunate whilst one remains whom the spoiler has not seized. (3.2)
Loss haunts Victor from a very early point in the book: his mother’s death is an "irreparable evil" from which all future evil and loneliness spring.