Victor, the monster, and the Fresh Prince of Bel-Air have one thing in common: Parents just don't understand. If only Victor's dad had taken the time to explain why Agrippa wasn't worth reading instead of just muttering about the trash kids these days read, maybe the whole tragedy would have been averted. Or so he says. Frankenstein might seem to suggest that having a good family is the solution to all of society's problems (like murderous monsters), but we're not so sure. The one nice family we see ends up exiled in a cottage in the middle of the woods. It's not much of an advertisement for family togetherness.
Victor's mother's death is the impetus for his creating the monster. Because such an event was beyond his control, Victor is morally exonerated from responsibility for the tragedy that follows.
Walton's need for a friend mirrors the need the monster has for a mate. Gender doesn't matter in Frankenstein's relationships: the point is closeness and intimacy, not sex.