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She died calmly, and her countenance expressed affection even in death. I need not describe the feelings of those whose dearest ties are rent by that most irreparable evil, the void that presents itself to the soul, and the despair that is exhibited on the countenance. It is so long before the mind can persuade itself that she whom we saw every day and whose very existence appeared a part of our own can have departed forever--that the brightness of a beloved eye can have been extinguished and the sound of a voice so familiar and dear to the ear can be hushed, never more to be heard. These are the reflections of the first days; but when the lapse of time proves the reality of the evil, then the actual bitterness of grief commences. Yet from whom has not that rude hand rent away some dear connection? And why should I describe a sorrow which all have felt, and must feel? The time at length arrives when grief is rather an indulgence than a necessity; and the smile that plays upon the lips, although it may be deemed a sacrilege, is not banished. My mother was dead, but we had still duties which we ought to perform; we must continue our course with the rest and learn to think ourselves fortunate whilst one remains whom the spoiler has not seized. (3.2)
Loss haunts Victor from a very early point in the book: his mother’s death is an "irreparable evil" from which all future evil and loneliness spring.
My temper was sometimes violent, and my passions vehement; but by some law in my temperature they were turned not towards childish pursuits but to an eager desire to learn, and not to learn all things indiscriminately. I confess that neither the structure of languages, nor the code of governments, nor the politics of various states possessed attractions for me. It was the secrets of heaven and earth that I desired to learn; and whether it was the outward substance of things or the inner spirit of nature and the mysterious soul of man that occupied me, still my inquiries were directed to the metaphysical, or in it highest sense, the physical secrets of the world. (2.4)
Somehow, we think Victor would have been better off memorizing train schedules or all the batting averages of the major league players. The "secrets of heaven and earth" are pretty heavy for a kid.
Such were the professor's words —rather let me say such the words of the fate —enounced to destroy me. As he went on I felt as if my soul were grappling with a palpable enemy; one by one the various keys were touched which formed the mechanism of my being; chord after chord was sounded, and soon my mind was filled with one thought, one conception, one purpose. So much has been done, exclaimed the soul of Frankenstein—more, far more, will I achieve; treading in the steps already marked, I will pioneer a new way, explore unknown powers, and unfold to the world the deepest mysteries of creation. (3.15)
The obvious problem here is the "deepest mysteries of creation": Shelley seems pretty convinced that we should let them stay mysterious. The second problem is the "one thought, one conception, one purpose"—it sounds like Victor really needs a hobby other than digging up corpses.