Gilgamesh is a recurring character in Final Fantasy series of video games. (With a buddy named Enkidu, natch.) In the video game Civilization IV, Gilgamesh is the leader of the Sumerian civilization. (source and source)
Canadian writer Michael Ondaatje, most famous for writing The English Patient, also wrote a novel called In The Skin Of A Lion. Besides being awesome, the title of In The Skin Of A Lion comes from a line in Gilgamesh. (source)
American writer Philip Roth's 1963 baseball novel The Greatest American Novel featured a character named Gil Gamesh, named after the ancient hero. (source)
Gilgamesh has been translated into Klingon. Of course. (We get the feeling the Klingons would have admired him—at least, his young, war-like self.) You can read it in this dual language edition: source.