There is a clear distinction between house and home in The Handmaid's Tale. Handmaids are placed in other people's homes, which to them are just houses. There's no reason for them to feel at home there. Strangely, one of the most home-like places in the restricted Republic of Gilead is a brothel, which used to be a hotel. It's full of references to the time before, like unchanged wallpaper and tiny soaps, which give it a feeling of familiarity and timelessness that's missing from the houses in which the Handmaids and Marthas work.
Once the narrator arrives at the Women's Center, the idea of ever having a place she could call "home" again is closed to her.