What happens in Island of the Blue Dolphins when two wildly different cultures are pitted against each other? In Round 1, the Aleuts take on the native islanders and literally massacre them. Culture clash, anyone? Yeah, you could say that. Neither culture can see the other's point of view, and the result is a bloody, destructive mess. Each sees the other culture as, well, "others." (That is, as different from them.)
In Round 2, however, Karana has a chance to adjust this point of view. Instead of clashing with the "others" – or foreigners – she learns to communicate with them. Karana tries to be friends with (not fight) others. Her relationship with the Aleutian girl Tutok teaches us that human connection is the most important thing of all.
Different cultures will struggle for power and resources when brought together in the same environment.
Cultures can understand each other through communication and empathy.