In the Gospel of Luke, the classic role of villain belongs to the Jewish leaders—also known as Pharisees, lawyers, scribes, chief priests, Sadducees, and other "leaders" (19:47; 23:13, 35). They oppose Jesus from the outset (6:11), are always grumbling about him under their breath (5:30; 15:2; 19:7), and in general are looking to utterly crush him (11:53-54; 19:47-48; 22:3-6).
The feeling is mutual. Jesus says these guys are totally corrupted by greed, love of money, and desire for honors (11:37-53; 16:14; 19:45-21:4) and that they're the most pretentious prigs around (18:9-14).
On the surface, it seems like the leaders come out victorious. But Jesus has something else to say about the situation. According to J-Man, Jerusalem will be destroyed (13:34-35; 19:41-42; 20:16; 21:6), and the leaders will be removed from power (20:16). So their success in getting Jesus's death is, for Luke, only temporary. Looks like the Good Guys will take it in the end, after all.
It's not hard to see that Luke paints the religious leaders with pretty large strokes of the brush. Unlike the disciples—who, granted, aren't the brightest crayons in the box—we see very little complexity or development for these guys. That means we have to be careful not to identify the Jewish leaders of this story with the historical figures. It's kind of impossible for real people to be flat characters, after all.
Plus, Luke does at least try to indicate that not all of the Jewish leaders are so bad. Examples?
So keep your eye out for the Anakin behind these Darth Vaders. Just don't hold your breath.