Macduff runs on stage looking for Macbeth (who is no longer on stage) and screams for the evil tyrant Macbeth to come out and show his ugly face.
Macduff says he's hot to kill Macbeth with his own sword because he'll likely be haunted by his wife and kids if he doesn't. He begs "fortune" to let him find Macbeth so he can stab him in the guts.