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Microorganisms: Viruses: '80s Retrovirus Party Quiz

Think you’ve got your head wrapped around Microorganisms: Viruses? Put your knowledge to the test. Good luck — the Stickman is counting on you!
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Q. Which of the following is MOST important in controlling virus infections?


B cells
CD4+ T cells
CD8+ T cells
NK cells
Innate immunity
Q. Why aren’t viruses that have latent stages of replication ever completely cleared by the immune system?


They stop replicating for indefinite periods of time.
They are mostly RNA viruses.
They are mostly DNA viruses.
They maintain a low level of replication that the immune system can’t completely remove.
They are insensitive to CTLs.
Q. What is responsible for presenting virus antigens for recognition by the immune system?


T cell receptor (TCR)
CD8
CD4
MHC
Interferon
Q. What are some reasons that some antivirals are not as useful against viruses as vaccines?


Viruses can easily mutate to become resistant against the antiviral.
Vaccines generate a broad immune response that recognizes more virus variants than antivirals.
Vaccines have a longer-lasting antiviral response than drugs.
Antivirals can be more toxic than vaccines.
All of the above
Q. Which of the following viruses would be more ideal to design an antiviral drug rather than a vaccine?


A virus that has a latent phase
A virus that inhibits the immune response
A DNA virus
A virus that does not have strong antigenic sites
All would be ideal antiviral targets.
Q. Which of the following viruses would be the most restricted by tetherin?


A DNA virus
An enveloped virus
A naked virus
An RNA virus
All of the above are restricted by tetherin.
Q. Which of the following viruses would be restricted by APOBEC?


Retrovirus
Picornavirus
Poliovirus
Herpesvirus
None of the above are restricted by APOBEC.
Q. Which of the following is NOT an immune defense mechanism against virus infection?


Skin
Virus receptors
Interferon
NK Cells
CTLs
Q. Which of the following is an example of antigenic shift?


Recombining of segmented genomes
Mutation by viral polymerase
Changing virus receptor
Entering by low pH mechanism
Silencing CTL response
Q. Which of the following reasons explains why smallpox was an ideal candidate to develop a vaccine against?


Conserved antigenic sites
Existing weakly pathogenic forms
Ease of growth in culture
All of the above
None of the above
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