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"Guys like us, that work on ranches, are the loneliest guys in the world. They got no family. They don't belong no place. They come to a ranch an' work up a stake and then they go inta town and blow their stake, and the first thing you know they're poundin' their tail on some other ranch. They ain't got nothing to look ahead to." (1.113)
It's hard out there for a ranchhand. Steinbeck seems to be saying that the loneliness is even worse than the poverty: like Lennie and George, you can bear a lot more if you have a friend.
"We travel together," said George coldly.
"Oh, so it's that way."
George was tense and motionless. "Yea, it's that way." (2.80-82)
By saying "Oh, so it's that way," Curley is essentially accusing Lennie and George of being gay. But George doesn't take the bait. It just shows how pathetic Curley is that he can't understand the men's friendship.
"It ain't so funny, him an' me goin' aroun' together," George said at last. "Him and me was both born in Auburn. I knowed his Aunt Clara. She took him when he was a baby and raised him up. When his Aunt Clara died, Lennie just come along with me out workin'. Got kinda used to each other after a little while." (3.12)
Aw. We can't think of a better description of friends than people who "got kinda used to each other."