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[He] walked heavily, dragging his feet a little, way a bear drags his paws. His arms did not swing at his sides, but hung loosely. (1.4)
Should we keep count? This is instance #1 of Lennie being compared to an animal—a bear, no less: a massive, occasionally violent creature.
His huge companion dropped his blankets and flung himself down and drank from the surface of the green pool; drank with long gulps, snorting into the water like a horse. The small man stepped nervously beside him. (1.5)
Instance #2 of Lennie being compared to an animal—this time, a horse who has to be kept from drinking too much water. There's a sense here, at least, that man has some responsibility to control the natural world.
Lennie dabbled his big paw in the water and wiggled his fingers so the water arose in little splashes; rings widened across the pool o the other side and came back again. Lennie watched them go. "Look, George. Look what I done." (1.9)
Lennie doesn't get hands—he gets "paws," and he's fascinated with how those paws can affect the natural world. It's also as though, like an animal, he doesn't quite understand cause-and-effect.