Nurse Ratched, the novel’s antagonist, maintains her power on the ward by manipulating the men’s fears and desires. She uses shame to keep them submissive. She manipulates her staff through insinuation and by carefully stroking their hatred. When she is unable to get the protagonist, McMurphy, under control, she tries to manipulate the other patients to turn against him by suggesting that he is manipulative himself and has never helped the men without getting something (like money) in return.
Even though Nurse Ratched is a master manipulator, she fails to convince the men that McMurphy himself is manipulating them for his own benefit.