Owen and John are quite a duo, aren't they? John seems so normal, and Owen seems so, well, strange, and yet they complement one another so well. Their friendship is central to A Prayer for Owen Meany. They are such good friends that they can both get over the fact that Owen is responsible for the death of John's mother. Of course, without their friendship, we wouldn't have much of a story, but that seems to be beside the point. Owen and John are truly invested in one another. Owen helps John figure out his identity, and he also saves his life by keeping him out of Vietnam. John, likewise, plays a key role in helping Owen to fulfill his destiny. These two are there for each other through thick and thin.
Owen is in charge of his friendship with Johnny.
Johnny and the Wheelwrights protect Owen.