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Ophelia and Hamlet move through the stage at a point in Act One. Hamlet pursues her, looking knock-kneed. He takes her hands and peruses her face. He lets her go and they exit the stage in opposite directions.
Ophelia only appears a few times in Act Two. First, she is in Claudius's procession, when he comes to check on how much Ros and Guil have found out about Hamlet.
Later she enters the stage with a prayer book. Hamlet approaches her and says, "Nymph, in thy orisons be all my sins remembered" (2.258). She replies, "Good my lord, how does your honor for this many a day?" (2.259).
Shortly after, she appears wailing. Hamlet pursues her and tells her there will be no more marriage. He suggests that either his mother or his uncle will die, and tells her to go to a nunnery. Claudius comes in and tells her that Hamlet is not in love with her, and that he is not mad.