On the fourth day from that time, Silas and Eppie, in their Sunday clothes, with a small bundle tied in a blue linen handkerchief, were making their way through the streets of a great manufacturing town. (2.21.7)
It's cliché to talk about being isolated in a big city, but that's exactly what's going on here. The city that Silas grew up in has changed so much that he's completely lost. The way of life that Raveloe offers is an idealized dream, but the alternative, the crowded-yet-lonely life of the city, seems almost like a nightmare. What's left for reality?