The Piano Lesson presents an interesting blend of spirituality. The presence of Christianity is definitely felt in the play, mostly through Avery, a black minister. However, the characters in the play blend other traditions with their understandings of Christianity. In the world of The Piano Lesson, ghosts can be seen as the hand of God as well as the Devil. The play also shows examples of African spiritual traditions such as ancestor worship. At the play's climax, the Christian God, ghosts, and the spirits of the ancestors are all called upon to help get rid of a particularly troublesome ghost.
When Berniece summons the spirits by playing the piano, she is instinctually practicing the ancient African tradition of ancestor worship.
At the climax of the play, Berniece finds a spiritual connection to the continent of Africa.