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If this title makes you think of Star Wars' C-3PO, then you're on the right track. Cyborgs abound in We3. It is a beautiful, violent graphic novel by famous comics writer Grant Morrison. Morrison's early work included a long, multi-part comic series titled Animal Man about a pro-animal superhero whose powers come from whatever animals are around him at any given time. Pretty cool stuff.
In a lot of ways We3 builds upon Wells's Doctor Moreau. It is Moreau set in the late twentieth-century—at a time when it's not lone, crazy scientists but the governments and militaries of the world that are pioneering new uses for animals—and turning them into trained killing machines. Yikes.
The novel features a cast of nonhuman protagonists including a rabbit, a dog, and a cat—the "3" of We3. The animals are armed to the teeth, smart, and are able to communicate with each other. It's only a matter of time before they go rogue and put the hurt on their human overlords.