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Death
As if the novel's other big themes didn't provide enough sadness, death is also a player in Love Medicine. In particular, there happen to be a ton of (possible?) suicides in the book, suggesting that, for some characters, meeting the Grim Reaper is preferable to what they were dealing with in life.
The living characters are often preoccupied by death and loss—although it's kind of noteworthy that they don't see death necessarily as the big end that some might. Oh, and there's the fact that resurrection kind of comes up a lot. Death and the afterlife loom large in the book, and the characters overall seem pretty interested in thinking about them.
Death is probably the least scary thing in these characters' lives, and the easiest to "overcome" through ideas like resurrection.
The book emphasizes suicides to underscore the overall vein of self-destructiveness that seems to run through the characters and their actions.
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