Father, Mother and Margo still can’t get used to the chiming of the Westertoren clock, which tells us the time every quarter of an hour. Not me, I liked it from the start; it sounds so reassuring, especially at night. (7/11/1942.1)
In her isolation from the outer world of Holland, Anne is comforted by the sounds of the outside world intruding in their isolated place. In her emotional isolation from her family and fellow Secret Annex inhabitants, Anne is finding feelings of companionship with inanimate objects, such as the clock and her diary.
We’re so fortunate here, away from the turmoil. We wouldn’t have to give a moment’s thought to all this suffering if it weren’t for the fact that we’re so worried about those we hold dear, whom we can no longer help. I feel wicked sleeping in a warm bed, while somewhere out there my dearest friends are dropping from exhaustion or being knocked to the ground. (11/19/1942.5)
Anne recognizes in an instant how different this "inside" world is from the world "outside." In hiding, she is isolated from the pain and suffering of others, which makes her feel both guilty and grateful.
Added to this misery there is another, but of a more personal nature, and it pales in comparison to all of the suffering I’ve just told you about. Still, I can’t help telling you that lately I’ve begun to feel deserted. I am surrounded by too great a void. I never used to give it much thought, since my mind was filled with my friends and having a good time. Now I think either about unhappy things or about myself. It’s taken a while, but I’ve finally realized that Father, no matter how kind he may be, can’t take the place of my former world. (11/20/1942.3)
Anne realizes that she is isolated from her family; without her friends that formerly gave her comfort, she feels very much alone.