Zoë ends up marrying Uncle Mike and moving to Greece to pop out four children.
Cal doesn't really care about her story, though—it's all about his parents, Milton and Tessie.
Milton converts Lefty's bar, the Zebra Room, into a diner, and kind of forces Lefty into retirement. Before Lefty leaves, he makes sure there are three insurance policies on the place. "You can never have too much insurance" (2.7.21), he says.
Without a job, Lefty starts gambling again. He pretty much loses every dime he and Desdemona have, and they have to move in with their children.