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Mortality
Cancer isn't always a death sentence, but sometimes cancer does, in fact, equal death. That's the grim equation the Fitzgerald family faces in My Sister's Keeper. Their daughter Kate is diagnosed with acute promyelocytic leukemia which sounds serious. And Kate's case is. She has to come to terms with facing her own death, and her parents have to face the death of their child. As this book shows us, death is sometimes more difficult for those who live.
Anna's death is the only way to end the novel because it's the only thing that gets the family to snap out of their selfish ways.
Anna's death is random, but it's no more random than cancer, or the car accident that gives Campbell epilepsy. Much as death is certain, when it appears almost always feels random.
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