A la Shmoop
We're talking biology with Dr. Ruth Tennen [David introduces Dr. Ruth Tennen]
and we're gonna talk now about biotechnology.
Okay, what is RNA interference? [Blood cells separate and the question appears on the screen]
So, RNA interference, or RNAi,
is a way of regulating or turning down
gene expression for specific genes
using double stranded RNA. [Dr. Ruth Tennen explains gene expressions using double stranded RNA]
Give us an example of a gene expression
you'd wanna turn down.
Okay, so let's say you had --
I'm gonna use a cancer example again.
Let's say you had a gene that you thought was required [A segment of RNA highlights]
for a cancer cell to be alive.
You could use RNA interference to turn off that gene, basically,
and see if the cancer cell was still able to survive.
[ shrieking ] [The bomb explodes and cancer cell is destroyed]
So, like the cancer cell lived off a certain type of carbon
- Sure. - or a certain type of whatever.
It would be something that would be like
- resistant to that carbon. - Mm-hmm. [David shows various hand gestures]
Yeah, and the cool thing about RNA interference --
Because you're not actually messing up the DNA, [DNA and RNA strands]
you're just messing up the RNA,
if you get rid of the, kind of, inducer,
if you get rid of the double-stranded RNA, [RNA strand drops down]
you can turn the gene back on.
So it's kind of a reversible or temporary change,
rather than getting rid of it.
Got it. Okay. Very cool.
[ whoop ]
What is RNA interference? [Questions on RNA Interference and gene expression appears on the screen]
What's an example of a gene expression you'd wanna turn down?
[ shrieking ]