"It is time," said Rezia.
The word "time" split its husk; poured its riches over him; and from his lips fell like shells, like shavings from a plane, without his making them, hard, white, imperishable words, and flew to attach themselves to their places in an ode to Time; an immortal ode to Time. (4.47-48)
Rezia’s efforts to get Septimus to the doctor are kind of futile. She can barely communicate with him, since he doesn’t take her words at face value.
Quote 2
Horror! horror! she wanted to cry. (She had left her people; they had warned her what would happen.) (1.84)
Rezia struggles with Septimus’ madness. She misses her sisters and Italy, and feels that she doesn’t deserve to suffer as much as she does. She's not only emotionally isolated, but physically isolates as well.
Quote 3
She was exposed; she was surrounded by the enormous trees, vast clouds of an indifferent world, exposed; tortured; and why should she suffer? Why? (4.36)
Rezia has no one to turn to. Her sisters are in Milan and she feels that London is a cold and unfriendly place.
Quote 4
One cannot bring children into a world like this. One cannot perpetuate suffering, or increase the breed of these lustful animals, who have no lasting emotions, but only whims and vanities, eddying them now this way, now that. (4.81)
Septimus and Rezia would never have children – that would mean bringing more suffering into the world. Human beings can only be miserable, they think.
Quote 5
She could not sit beside him when he stared so and did not see her and made everything terrible; sky and tree, children playing, dragging carts, blowing whistles, falling down; all were terrible. (1.66)
Septimus’ madness ruins everything. Rezia cannot enjoy the simplest of everyday things knowing that Septimus is crazy, and getting worse.