How we cite our quotes: All quotations are from The Big Lebowski.
Quote #10
THE DUDE: You thought that Bunny had been kidnapped, and you were f***ing glad, man. It was an excuse to make some money disappear, and all you needed was a sap to pin it on. You just met me, you … you human paraquat.
Paraquat is an herbicide that The Dude might know about because the U.S. sprayed it on marijuana fields in Mexico in the '70s. (Source) So this is a huge insult from his point of view. The Dude lets Big have it for all his lying and scheming that dragged the poor Dude out of his comfortable life and into the world of lawlessness and disorder.