A Left-Handed Commencement Address: Questions

How does "A Left-Handed Commencement Address" depart from typical commencement addresses?
Should we categorize Le Guin's books, like her Left Hand of Darkness to which her speech title refers, as science fiction? Do her works follow the rules for that genre?
Did Mills College know Le Guin was going to (:::clutches pearls:::) speak in public in the language of women?
Which came first: Le Guin, or Second-Wave Feminism?
Why do "human beings grow human souls" in the darkness? What could Le Guin mean by that?