Quote 1
MR. FRANK: To be perfectly safe, from eight in the morning until six in the evening we must move only when necessary and then in stockinged feet. We must not speak above a whisper. We must not run any water. (1.2)
Mr. Frank lays down the rules for isolation in the Annex. No talking, moving, farting, etc. The Nazis will find you, and they will kill you.
Quote 2
MR. FRANK: This is the way we must live until it is over, if we are to survive. (1.2)
Come with me if you want to live. Actually, go with Otto Frank. He knows better than the Terminator how to survive a world war.
Quote 3
MR. FRANK: I don't want you to ever go beyond that door. (1.2)
The Annex is completely isolated. Anne has to listen to her dad and never go beyond the door that is hidden behind the bookcase in his former office.