The qualifications are relatively basic for entry-level positions: a high-school diploma and some office experience or computer skills may land you a gig. If you want some real responsibility, though, the credentials needed are going to go up. For one thing, you may need experience to learn the ins and outs of being an Administrative Assistant. You can also improve your résumé by taking computer classes, and by learning applications like word processing or database management. You could also shoot for a specialty position in the medical or legal field by taking classes in their particular jargon.