Topics in Depth
The Theme of Modification of Dominance Relationships in Genetics
As it turns out, Mendel was a lucky man. He picked, partly by accident, characters and corresponding alleles that showed simple relationships between dominance and recessiveness. Often, different alleles in a heterozygous state are capable of some degree of expression; one allele is not necessarily completely dominant over the other. Thus, a heterozygote genotype gives rise to a phenotype that is different from what each allele produces in the homozygous state. These alleles can be codominant or incompletely dominant.
In codominance, both alleles are expressed and appear in the heterozygote. Human ABO blood types are one example of where this occurs. Blood type in this case is determined by a single locus, where three different alleles are possible (IA, IB, IO). IO is completely recessive to both IA and IB, so an IAIO individual is phenotypically A and an IBIO individual is phenotypically B. However, an individual whose genotype is IAIB, is phenotypically AB, as the IA and IB alleles are codominant.
To understand why this is the case, its necessary to look at ABO gene function. It may all sound a bit "Old MacDonald's Farm" with all these IAs and IOs, but bear with us on this one! What are blood types about anyway? Vampire lore says different blood types have different flavors – well, maybe, if you're a vampire with a particularly sensitive palate. But for us regular, everyday mortals, the important point is this: the different blood groups have different kinds of proteins, called antigens, on the surface of their blood cells. The IA allele codes for the production of A antigens, IB for B antigens, while IO does not produce any kind of antigen at all. Also, the immune systems of individuals with different blood groups produce different antibodies (proteins that identify and help neutralize foreign objects and cells). Individuals with blood type A produce antibodies against B antigens, individuals with blood type B produce antibodies against A antigens, but individuals with blood type AB do not produce antibodies against either A or B antigens (because it would be a bit of a disaster all round for them if they did). Individuals with blood type O produce antibodies against both A and B antigens. This is why people with AB blood type are universal receivers; they can receive blood transfusions from any blood group precisely because they produce no anti-blood group antibodies. On the other hand, people with O blood types are universal donors: anyone can receive their blood because it can't provoke an immune response, thanks to having no antigens on the surface of its blood cells.
When alleles show incomplete dominance, the phenotype of the heterozygote is intermediate in nature between those produced by the homozygous genotypes. This is because the heterozygote has only one functional copy of the gene and thus produces half the protein. Think of it as a dosage problem: instead of two teaspoons of cough syrup (homozygote for cough syrup dose), you get a teaspoon of cough syrup and a teaspoon of water (heterozygote for cough syrup dose), or two teaspoons of water (no cough syrup at all - ouch!).
Let's look at a real example: if a true-breeding red snapdragon (RR) is crossed to a true-breeding white snapdragon (WW), all of the resulting F1 are pink (RW). The pink simply results from producing half the amount of red pigment. It is tempting however to think it works just like paint – red paint mixed with some white paint produces pink paint; in fact, before the advent of Mendel's discoveries, many believed in such "blending inheritance" - the phenotype of an offspring results from the mixing of the parent's phenotypes and thus is often intermediate. However, further analysis of this character reveals it is consistent with Mendelian principles. If the pink F1 individuals (RW) are interbred to produce an F2 generation, 50% of the resulting plants have pink flowers (RW), 25% have red flowers (RR), and 25% have white flowers (WW). The F1 plants produced gametes carrying R and W in equal numbers, that when mixed up to produce new plants generate the same genotypic ratios as with the traditional Mendelian traits. As in codominance, however, because the heterozygote produces a different phenotype than the homozygous dominant, the phenotypic ratios exactly match the genotypic ratios (which they don't do in a standard dominant/recessive relationship).
When does it come in handy to carry a potentially dangerous allele? Sickle cell disease (also known as sickle cell anemia) is serious illness caused by a mutation in the gene for the hemoglobin β chain. The mutant allele, HbS, is codominant with the normal allele, HbA, and heterozygotes (HbAHbS) are said to have sickle cell trait, a relatively harmless condition that actually gives the affected person protection against malaria!
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