- What does the title mean? How does Dolores "come undone"? Does it happen all at once, or is it a gradual process? How does she put herself back together?
- Does Lamb accurately capture a female voice?
- How would this book have been different if it were written by a woman? Or if Dolores was a male protagonist (Donald Price, perhaps)?
- Why is the book divided into three parts? How does each part correspond with a stage of Dolores's life?
- Do you think Dolores and Thayer will live happily ever after or merely happily for now? What do you think would happen in a She's Come Undone sequel? (She's Come Undone… Again!, She Keeps Coming Undone!, She's Come Undone-r, Undone 2: The Second One)
- Where do whales appear in the story? When are they stuck, in need of help, dying, or free? How does Dolores's attitude toward whales change over the course of the novel?
- The book has been in print for decades, but there hasn't been a movie. Why do you think this is? Who would you cast?