In Choose Your Own Woman: Of Mice and Men, you have two options: a prostitute, or Curley's wife. There's no such things as a nice girl to settle down with, if your life is spent moving from ranch to ranch on the open road. So, women are reduced purely to sexual objects—and at least with prostitutes, George says, you pay for what you get. Curley's wife is a sexual object, but all she can really offer is trouble. We get the feeling that the characters in Of Mice and Men would really be better off without women.
Curley's wife may be an awful woman, but she does suffer from real affliction and prejudice. Steinbeck uses her to illustrate the difficulties women faced during the Great Depression.
In Of Mice and Men, the only good woman is a dead woman.